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TranscriptomicsAntisense Transcripts Impede Uridylation-induced Exonucleolytic Degradation to Generate Guide RNAs
Small non-coding RNA biogenesis typically involves cleavage of structured precursors by RNase III-like endonucleases. However, guide RNAs that direct U-insertion/deletion mRNA editing in mitochondria of trypanosomes maintain 5′ triphosphate characteristic of transcription start site and possess U-...
ORGANISM(S): Trypanosoma brucei 
2016-02-08 | E-GEOD-71292 | biostudies-arrayexpress
TranscriptomicsDifferentiated Truncation and Uridylation Patterns of miRNAs in Arabidopsis and Rice hen1 Mutants Suggest miRNAs May Re-program RISC
miRNA levels depend on both biogenesis and turnover. The methyltransferase HEN1 stabilizes plant miRNAs, animal piRNAs, and siRNAs in both kingdoms via 3' terminal methylation. Loss of HEN1 in plants results in non-templated oligo-uridylation and accelerated degradation of miRNAs. In hen1 mutants fr...
ORGANISM(S): Arabidopsis thaliana 
2013-07-22 | E-GEOD-35562 | biostudies-arrayexpress
TranscriptomicsSmall RNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precursor...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-35835 | biostudies-arrayexpress
Genomics3’ Uridylation Expands miRNA Target Repertoire
3’ Uridylation Expands miRNA Target Repertoire
PRJNA497065 | ENA
TranscriptomicsmRNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precur...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40228 | biostudies-arrayexpress
TranscriptomicsGlobal view of mRNA uridylation in Arabidopsis
To obtain a global view of mRNA uridylation in Arabidopsis, we generated TAIL-seq libraries from WT plants, urt1 and xrn4 single mutants, and urt1 xrn4 double mutant. The TAIL-seq protocol was recently developed to deep-sequence the 3' ends of RNAs (Chang et al., 2014). We generated TAIL-seq librari...
ORGANISM(S): Arabidopsis thaliana 
2016-03-11 | E-GEOD-72457 | biostudies-arrayexpress
TranscriptomicsSequence-specific mono-uridylation of mature miRNAs by Zcchc6 and Zcchc11
Recent small RNA sequencing data has uncovered extensive modification of the 3’ end of mature microRNAs (miRNAs). This non-templated nucleotide addition can impact miRNA gene regulatory networks through the control of miRNA stability or by interfering with the repression of target mRNAs. The miRNA m...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52575 | biostudies-arrayexpress
TranscriptomicsUridylation by TUT4 and TUT7 marks mRNA for degradation [RNA-Seq]
Uridylation occurs pervasively on mRNAs in mammals, yet its mechanism and significance remain unknown. Here we identify TUT4 and TUT7 (also known as ZCCHC11 and ZCCHC6, respectively) as the enzymes that uridylate mRNAs. Uridylation readily occurs on deadenylated mRNAs that are not associated with po...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-59626 | biostudies-arrayexpress
GenomicsInvolvement of Arabidopsis TUTases in viral RNA uridylation
Involvement of Arabidopsis TUTases in viral RNA uridylation
PRJNA875113 | ENA
GenomicsRNA uridylation percentages for virus of the Secoviridae family
RNA uridylation percentages for virus of the Secoviridae family
PRJNA875114 | ENA
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