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TranscriptomicsAnalysis of microRNA expression in ADPKD patient derived urinary exosomes by RNAseq
This experiment was designed to identify changes in microRNA expression in patients with early or late stage ADPKD vs healthy controls. microRNA was isolated from urinary exosomes before high throughput sequencing. Expression levels was analysed using STRAND NGS software.
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-8109 | biostudies-arrayexpress
ProteomicsProteomic analyses of urinary exosomes identify heparanase, cathepsin C, 2-macroglobulin and sarcoplasmic endoplasmic Ca2+ ATPase-3 (SERCA3) as potential biomarkers for early diagnosis of sickle nephropathy
Sickle cell disease-induced nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell disease (SCD). Early intervention is crucial for mitigating its effects. However, current diagnostic methods rely on non-specific tests and may not detect SCN until renal damage has become irre...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-07 | PXD043401 | JPOST Repository
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD002645 | Pride
Human Ubiquitylated proteins Urine Exosomes 
TranscriptomicsIdentification of urinary exosomal microRNAs associated with subclinical acute T-cell-mediated rejection in kidney transplant recipients
This study aimed to evaluate the diagnostic utility of urinary exosomal microRNAs (miRNAs) in subclinical rejection following kidney transplantation by comparing miRNA expression profiles in urinary exosomes between patients with no evidence of rejection and patients with subclinical T-cell-mediated...
ORGANISM(S): Homo sapiens 
2025-12-04 | E-MTAB-16238 | biostudies-arrayexpress
ProteomicsComprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Noninvasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model
To investigate the potential noninvasive early biomarkers of AD in 5XFAD mouse model, we investigate the proteome of urinary exosomes present in 1-month-old (before amyloid-β accumulation) 5XFAD mouse models and their littermate controls. Another two groups of 2 and 6 months-old urinary samples were...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021935 | Pride
Urinary exosome proteome Alzheimer’s disease 5xfad mouse model Early diagnosis Biomarkers 
ProteomicsQuantitative proteomic analysis of urinary exosomes from patients with primary aldosteronism that underwent fludrocortisone suppression test
The sodium chloride cotransporters (NCC) and the epithelial sodium channel (ENaC) have been reported to be the main effectors of aldosterone in Na+ and Cl- reabsorption in the distal nephron and dietary K+ downregulates NCC. The Cl-/HCO3- exchanger pendrin has been revealed as a key role in maintain...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD017083 | Pride
Human Exosomes Urine Kidney 
ProteomicsProteomic analysis of urinary exosomes in cystinuria patients
Cystinuria is a rare renal genetic disease caused by mutations in cystine transporter genes and characterized by defective cystine reabsorption leading to kidney stones. In 14% of cases patients undergo nephrectomy, but given the difficulty to predict the evolution of the disease, the identification...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079546 | MassIVE
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080269 | MassIVE
GenomicsmiRNA profiling of urinary exosomes to assess the progression of acute kidney injury
miRNA profiling of urinary exosomes to assess the progression of acute kidney injury
PRJNA513035 | ENA
TranscriptomicsDifferential miRNA expression profiling of urinary exosomes from normo- and microalbuminuric type 1 diabetic patients
The aim of this study was to compare miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Overnight urine collections were obtained from normo- and microalbuminuric type 1 diabetic patients. Urines were pre-cleared by both centrifugation...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-48318 | biostudies-arrayexpress
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