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MetabolomicsNon-invasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer
Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1500 Da) were measured in urine collected from 469 lung cancer patients and 536 population controls using u...
2014-05-06 | MTBLS28 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Urease pre-treatment of urine has been utilized since the early 1960s to remove high levels of urea from samples prior to further processing and analysis by gas chromatography–mass spectrometry (GC–MS). Aside from the obvious depletion or elimination of urea, the effect, if any, of urease pre-treatm...
2014-05-21 | MTBLS71 | MetaboLights
Metabolomics1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats

BACKGROUND: Protein undernutrition is prevalent mainly among elderly people, and it could develop diseases such as sarcopenia. Urinary metabolites may become biomarkers reflecting protein undernutrition, but this has been insufficiently investigated.

OBJECTIVE:

2021-05-27 | MTBLS1452 | MetaboLights
MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
Metabolomics1H NMR based urinary metabolites profiling dataset of canine mammary tumors

The identification of efficient and sensitive biomarkers for non-invasive tests is one of the major challenges in cancer diagnosis. To address this challenge, metabolomics is widely applied for identifying biomarkers that detects abnormal changes in cancer patients. Canine mammary tumors exhibit ...

2022-02-24 | MTBLS2550 | MetaboLights
ProteomicsHuman Urinary Proteome in Vesicoureteral Reflux
Vesicoureteral reflux (VUR) is a common pediatric condition that predisposes children to renal damage after urinary tract infection (UTI). We profiled the urinary proteome of VUR patients with recurrent UTI and renal scarring to identify potential biomarkers characterizing this condition. Urine was...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD010469 | Pride
Kidney damage Urine Vesicoureteral reflux Urinary tract infection 
ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
ProteomicsUrinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications
Various urinary parameters have been used to determine kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. We hypothesized that urinary macromolecules (especially proteins) also play a critical role in determinin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD050609 | Pride
Nephrolithiasis  oxidized protein  risk factor  stone modulator  urinary protein  urolithiasis 
ProteomicsOxidative modifications of urinary proteins increase kidney stone risk
Clinical and animal studies have demonstrated the increasing evidence of oxidative stress in kidney stone disease. Recent findings have shown that the interactions between calcium oxalate (CaOx) crystals and renal tubular cells can promote many cellular events such as cell proliferation, cell death,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019360 | Pride
Calcium oxalate  kidney stone  oxidative stress  post-translation modification  uromodulin 
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