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MetabolomicsHarnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation

Proteus mirabilis is a predominant cause of catheter associated urinary tract infection (CAUTI), and a key virulence factor is its urease enzyme which hydrolyzes urea to ammonia. This process results in the formation of urinary stones, facilitating catheter blockage and bacteremia. The o...

2025-08-29 | MTBLS891 | MetaboLights
ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
TranscriptomicsTranscriptome of Proteus mirabilis in the murine urinary tract
The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In the study, microrarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice. Urine was collected at 1, 3, and 7d postinfection, and RNA was isolated from bac...
ORGANISM(S): Proteus mirabilis 
2011-11-29 | E-GEOD-25977 | biostudies-arrayexpress
TranscriptomicsEscherichia coli global gene expression in urine from women with urinary tract infection
Examination of E. coli transcripts present in bacteria in urine samples from 8 patients attending a urology clinic with symptoms of cystitis, as compared to transcripts present in the same E. coli strains during mid-exponential growth in filter-sterilized human urine in vitro. A 48 array study using...
ORGANISM(S): Escherichia coli 
2010-11-12 | E-GEOD-24478 | biostudies-arrayexpress
ProteomicsUrinary proteome of suspected urinary tract infection (UTI) cases and healthy cohort
LC-MS/MS spectra obtained from urinary pellets of 110 suspected urinary tract infection (UTI) cases and five healthy individuals (PMC4396075; PMC5197061).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-02-06 | MSV000082031 | MassIVE
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
GenomicsWhole genome sequencing of urinary tract infection (UTI) microcolonies used for Microcolony-seq
Urine from a patient with a urinary tract infection was plated on LB agar plate. Microcolonies appeared ~8h after plating. Microcolonies were picked and subjected to Microcolony-seq and to whole-genome sequencing. Genomic DNA of each UTI microcolony was extracted from 1 mL of bacteria using the DNea...
ORGANISM(S): mixed sample 
2025-08-27 | E-MTAB-13941 | biostudies-arrayexpress
TranscriptomicsExpression data for UPEC and GBS cystitis in female C57BL/6 mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female C57BL/6 mice using genome-wide expression profiling and temporal analysis to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-27575 | biostudies-arrayexpress
TranscriptomicsMicrocolony-seq applied on a clinical urinary tract infection
Urine was obtained from a patient with a urinary tract infection and frozen in 15% glycerol at -80C. For the Microcolony-seq experiment a sample from the frozen urine was serially diluted four times 10-fold and plated on an LB agar plates and incubated at 37C. After 8 hours of incubated microcolonie...
ORGANISM(S): mixed sample 
2025-08-27 | E-MTAB-13892 | biostudies-arrayexpress
ProteomicsHuman Urinary Proteome in Vesicoureteral Reflux
Vesicoureteral reflux (VUR) is a common pediatric condition that predisposes children to renal damage after urinary tract infection (UTI). We profiled the urinary proteome of VUR patients with recurrent UTI and renal scarring to identify potential biomarkers characterizing this condition. Urine was...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD010469 | Pride
Kidney damage Urine Vesicoureteral reflux Urinary tract infection 
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