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TranscriptomicsThe chromatin protein Nupr1 regulates RelB-dependent NF-kB events necessary for pancreatic cancer development
The objective of this study was to elucidate the role of Nupr1 in pancreatic tumorigenesis. Using the Pdx-1-cre;LSL-KrasG12D mouse as model we discovered that, in contrast to KrasG12D pancreas that develop multiple foci of pancreatic intraepithelial neoplasia (PanIN), KrasG12D;Nupr1KO pancreas were ...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-35463 | biostudies-arrayexpress
TranscriptomicsRNA-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele
Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unkno...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10896 | biostudies-arrayexpress
GenomicsChIP-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele
Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unkno...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10901 | biostudies-arrayexpress
TranscriptomicsRRBS of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele
Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unkno...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10900 | biostudies-arrayexpress
TranscriptomicsCell cannibalism, a cell-death process driven by the Transforming Growth Factor-M-NM-2 and the Nuclear Protein 1, opposes to metastasis in pancreatic cancer
Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their physiological dedifferentiation towards a mesenchyma...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-38772 | biostudies-arrayexpress
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