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ProteomicsA Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage
Proteolytic processing is a critical regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying these events often remain elusive. Silencing Defective 2 (SDE2) is an essential human protein involved in multiple aspects of genome regulation, including DNA repair,...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD072107 | Pride
Hdx-ms Sde2 Usp5 Ubiquitin 
TranscriptomicsTranscription profiling by array to investigate USP5 knock out in cardiomycytes
The experiment compares cardiomyocytes isolated from Control and USP5 KO mice 15 days after deletion by tamoxifen administration.
ORGANISM(S): Mus musculus 
2024-12-14 | E-MTAB-6839 | biostudies-arrayexpress
ProteomicsUSP5 Stabilizes YTHDF1 to Control Cancer Immune Surveillance through mTORC1-mediated Phosphorylation
The N6-methyladenosine (m6A) binding protein YTHDF1 emerges as a frequently upregulated oncogene across various cancer types. Its depletion significantly improves the efficacy of cancer immune checkpoint blockade (ICB) treatment. A comprehensive understanding of the molecular mechanisms governing YT...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057917 |
ProteomicsERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases for regulating PD-1 stability have been reported, deubiquitinase (DUB) governing PD-1 homeostasis to modulate tumor immunotherapy...
ORGANISM(S): Homo Sapiens 
2023-03-17 | PXD040671 |
GenomicsWT/Usp5-MKO PM cells were stimulated with LPS or not
WT/Usp5-MKO PM cells were stimulated with LPS or not
PRJNA1004543 | ENA
GenomicsUSP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
PRJNA1166174 | ENA
GenomicsUSP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
PRJNA1077248 | ENA
GenomicsWT or Usp5 knockout (KO) PMs were infected with HSV-1 or not
WT or Usp5 knockout (KO) PMs were infected with HSV-1 or not
PRJNA978004 | ENA
OtherUSP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
N6-methyladenosine (m6A) binding protein YTHDF1 is frequently upregulated in various cancers and its depletion enhances the efficacy of immune checkpoint blockade (ICB) therapy. This study reveals that USP5 interacts with YTHDF1, preventing its K11-linked polyubiquitination, thereby stabilizing YTHD...
ORGANISM(S): Mus musculus 
2024-12-05 | GSE278264 | GEO
TranscriptomicsUSP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
The N6-methyladenosine (m6A) binding protein YTHDF1 emerges as a frequently upregulated oncogene across various cancer types. Its depletion significantly improves the efficacy of cancer immune checkpoint blockade (ICB) treatment. A comprehensive understanding of the molecular mechanisms governing YT...
ORGANISM(S): Mus musculus 
2024-12-11 | GSE255922 | GEO
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