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GenomicsElevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
PRJNA488607 | ENA
UnknownMutation enrichment in human DNA samples via UV-mediated cross-linking.
Not available
S-EPMC8989544 | biostudies-literature
OtherElevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites. While sometimes interpreted as functional dri...
ORGANISM(S): Homo sapiens 
2018-12-03 | GSE119249 | GEO
UnknownMutation accumulation under UV radiation in Escherichia coli.
Not available
S-EPMC5674018 | biostudies-literature
UnknownBiochemical and photochemical mechanisms that produce different UV-induced mutation spectra.
Not available
S-EPMC8671204 | biostudies-literature
UnknownCTCF binding modulates UV damage formation to promote mutation hot spots in melanoma.
Not available
S-EPMC8521319 | biostudies-literature
GenomicsOryzias latipes strain:Cab strain
left arm of chr19 sequencing, UV-induced mutation frequency in Olrev3l deficient cells
PRJDB6514 | ENA
UnknownExome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes.
Not available
S-EPMC7080724 | biostudies-literature
UnknownMultiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load.
Not available
S-EPMC6944116 | biostudies-literature
UnknownA ΔdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation.
Not available
S-EPMC4172556 | biostudies-literature
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