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UnknownIntraoperative transfusion practices in Europe.

Background

Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC...
S-EPMC4718146 | biostudies-literature
UnknownIntraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study.
The demographic development suggests a dramatic growth in the number of elderly patients undergoing surgery in Europe. Most red blood cell transfusions (RBCT) are administered to older people, but little is known about perioperative transfusion practices in this population. In this secondary analysi...
S-EPMC8726458 | biostudies-literature
UnknownEarly Treatment with Pegylated Interferon Lambda for Covid-19.

Background

The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.

Methods

We conducted a randomized, controlled, adaptive platform trial involving predominantly...
S-EPMC9933926 | biostudies-literature
UnknownEffect of Early Treatment with Ivermectin among Patients with Covid-19.

Background

The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.<...
S-EPMC9006771 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.

Background

Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody with highest affinity for aggrega...
S-EPMC10794000 | biostudies-literature
UnknownOral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.

Background

Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.

Objective

To determine whether the combination of fluvoxamine and inhaled budesonide would increase treatme...
S-EPMC10111398 | biostudies-literature
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