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TranscriptomicsGene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with NonSmall Cell Lung Cancer.
We report a 29-gene diagnostic signature, which distinguishes individuals with NSCLC from controls with non-malignant lung disease with 91% Sensitivity, 79% Specificity and a ROC AUC of 92%. Accuracy on an independent set of 18 NSCLC samples from the same location was 79%. Samples from an independe...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-13255 | biostudies-arrayexpress
TranscriptomicsWhole blood microRNA expression in human lung cancer
Seventh generation Exiqon locked nucleic acid miRCURY LNA microarrays were used to profile the expression of microRNAs in whole blood of patients with lung cancer and of clinically relevant controls without the disease (individuals with non-cancerous lung nodule, at high risk for cancer because of h...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40738 | biostudies-arrayexpress
UnknownWhole blood microRNA expression in human lung cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-40738 | biostudies-other
TranscriptomicsResection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System
We have examined the changes that occur in microRNA (miRNA) expression levels in peripheral blood mononuclear cells (PBMC) collected from paired pre- vs. post-tumor removal samples in order to characterize the way lung tumor removal affects gene expression in peripheral immune cells. 5 miRNAs were...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27606 | biostudies-arrayexpress
TranscriptomicsValidation of an Airway Gene Expression Classifier for Lung Cancer in Patients Undergoing Diagnostic Bronchoscopy
BACKGROUND: In patients with suspicious pulmonary lesions, bronchoscopy is frequently non-diagnostic. This often results in additional invasive testing, including surgical biopsy, although many patients have benign disease. We sought to validate an airway gene-expression classifier for lung cancer ...
ORGANISM(S): Homo sapiens 
2015-05-17 | E-GEOD-66499 | biostudies-arrayexpress
TranscriptomicsExpression data from Hif 2alpha Knockdown study
Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. The oxygen-sensitive Hypoxia Inducible Factor (HIF) transcriptional regulators HIF-1α and HIF-2α are overexpressed in many human NSCLCs, and constitutive HIF-2α activity can promote murine lung tumor progression,...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-22575 | biostudies-arrayexpress
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