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Transcriptomicsnext generation sequencing facilitates quantitative analysis of control and TKO liver transcriptomes
We used RNAseq to analyse the transcriptomes of cycling and quiescent livers from cTKO (Rblox/lox;p130lox/lox;p107?/?) and control mice. mRNA profiles of cycling and quiescent control and TKO liver tissue were generated by deep sequencing in duplicate
ORGANISM(S): Mus musculus 
2014-07-12 | E-GEOD-43631 | biostudies-arrayexpress
TranscriptomicsExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Cancer-associated fibroblasts (CAFs) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directl...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48397 | biostudies-arrayexpress
TranscriptomicsThe long non-coding RNA lnc277 mediates a repressive gene signature in Ewing's sarcoma and is required for oncogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-60891 | biostudies-arrayexpress
TranscriptomicsLentiviral shRNA knockdown of PTK7 in lung adenocarcinoma cell lines NCI-H1299 and NCI-H2009
PTK7 was identified from a meta-analysis of 1905 non-small-cell lung cancer (NSCLC) samples across 12 datasets to be one of seven genes commonly up-regulated in lung adenocarcinoma (ADC). Using ADC cell lines NCI-H1299 and NCI-H2009, disruption of PTK7 resulted in decreased cell viability and induct...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-50138 | biostudies-arrayexpress
TranscriptomicshnRNPK knock down in Ewing cell line
Ewing sarcoma is a highly aggressive tumor characterized by a translocation between members of the FET family of RNA binding proteins and one of several ETS transcription factors, with the most common translocation being EWS-FLI1. EWS-FLI1 leads to changes in gene expression through mechanisms that ...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-60890 | biostudies-arrayexpress
TranscriptomicspMPC EF vs control 3seq
Ewing sarcoma is a highly aggressive tumor characterized by a translocation between members of the FET family of RNA binding proteins and one of several ETS transcription factors, with the most common translocation being EWS-FLI1. EWS-FLI1 leads to changes in gene expression through mechanisms that ...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-60889 | biostudies-arrayexpress
GenomicsLocalization of the Rb tumor suppressor in MEFs during reprogramming to iPS and the consequence of Rb loss on the transcriptional profile and histone landscape in these cells
The reprogramming of differentiated cells to an embryonic stem cell-like state provides a powerful system to explore fundamental mechanisms of development, including how mammalian cells establish and maintain pluripotency and long-term self-renewal capability. Based on the similarities between embry...
ORGANISM(S): Mus musculus 
2014-11-13 | E-GEOD-40594 | biostudies-arrayexpress
GenomicsSCLC_SNP_6.0 - samples
SNP 6.0 arrays of small cell lung cancer
EGAD00010000558 | EGA
Genomicsena-DATASET-RTL-11-03-2015-12:07:49:303-16 - samples
Whole genome sequencing was performed with DNA extracted from fresh-frozen tumor and normal material. Short insert DNA libraries were prepared with the TruSeq DNA PCRfree sample preparation kit (Illumina) for paired-end sequencing at a minimum read length of 2x100bp. Human DNA libraries were sequenc...
EGAD00001001273 | EGA
Genomicsena-DATASET-RTL-06-02-2015-14:59:15:066-180 - samples
RNA-sequencing (RNA-seq) was performed with RNA extracted from fresh-frozen human tumor tissue samples. cDNA libraries were prepared from poly-A selected RNA applying the Illumina TruSeq protocol for mRNA. The libraries were then sequenced with a 2 x 100bp paired-end protocol to a minimum mean cover...
EGAD00001001244 | EGA
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