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TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
TranscriptomicsA point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-14394 | biostudies-arrayexpress
TranscriptomicsAnalysis of single CD41 cell transcriptomes from Zebrafish
Transcriptome data from individual CD41 expressing cells isolated from kidney and heart of zebrafish. CD41 is a marker both for HSCs and thrombocytes, and with this data we study thrombocyte development as a continuous process. Single cell transcriptomes are matched with flourescence of a CD41:GFP r...
ORGANISM(S): Danio rerio 
2016-01-08 | E-MTAB-3947 | biostudies-arrayexpress
TranscriptomicsMERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
Several previous studies have noted a rare sub-population of murine Embryonic Stem Cells (mESCs) which seem to express genes otherwise specific to the 2-cell stage of embryonic development. Here we sorted single cells from a MERVL/Zscan4 reporter line to investigate the continuum of expression as ce...
ORGANISM(S): Mus musculus 
2016-09-30 | E-MTAB-5058 | biostudies-arrayexpress
GenomicsIdentification of genome wide targets of the hox protein Ultrabithorax (Ubx) in larval wing buds of Bombyx mori (Daizo)
Amongst the various different insect groups, there is remarkable diversity in the number and size of wings. However the development of the basic body plan in insects is similar to a large extent. The genes of the hox complex regulate various pathways to bring about the development or modification of...
ORGANISM(S): Bombyx mori 
2016-07-27 | E-GEOD-71990 | biostudies-arrayexpress
UnknownUnidirectional animal-to-human transmission of methicillin-resistant Staphylococcus aureus ST398 in pig farming; evidence from a surveillance study in southern Italy.
Not available
S-EPMC6873530 | biostudies-literature
UnknownMixture-of-experts graph transformers for interpretable particle collision detection.
Not available
S-EPMC12314041 | biostudies-literature
UnknownPrevalence, molecular epidemiology, and antimicrobial resistance of methicillin-resistant Staphylococcus aureus from swine in southern Italy.
Not available
S-EPMC6390553 | biostudies-literature
TranscriptomicsExpression data in Staphylococcus aureus-infected mice with linezolid and vancomycin treatment
The precise mechanism and effects of antibiotics in host gene expression and immunomodulation in MRSA infection is unknown. Using a well characterized Methicillin Resistant Staphylococcus aureus (MRSA) isolate USA300 in a murine model of infection, we determined that linezolid and vancomycin induced...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-38531 | biostudies-arrayexpress
UnknownPatient preference in allergen immunotherapy - Understanding the patient's view.
Not available
S-EPMC12765409 | biostudies-literature
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