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ProteomicsDeletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum
Gas fermentation has emerged as a sustainable route to produce fuels and chemicals by recycling inexpensive one-carbon (C1) feedstocks from gaseous and solid waste using gas-fermenting microbes. Currently, acetogens that utilise the Wood-Ljungdahl pathway to convert carbon oxides (CO and CO2) into v...
ORGANISM(S): Clostridium autoethanogenum 
2023-05-10 | PXD040151 | Pride
Gas fermentation  acetogen  crispr/ncas9  genetic engineering  metabolomics  proteomics  chemostat  continuous cultivation  syngas 
ProteomicsRedox controls metabolic robustness in the gas-fermenting acetogen Clostridium autoethanogenum
Living biological systems display a fascinating ability to self-organise their metabolism. This ability ultimately determines metabolic robustness that is fundamental to control cellular behaviour. However, fluctuations in metabolism can affect cellular homeostasis through transient oscillations. Fo...
ORGANISM(S): Clostridium autoethanogenum 
2020-05-18 | PXD016381 | Pride
Metabolic robustness  oscillations  acetogen  gas fermentation  wood-ljungdahl pathway  metabolism  data-independent acquisition 
ProteomicsAbsolute proteome quantification in the gas-fermenting acetogen Clostridium autoethanogenum
Microbes that can recycle one-carbon (C1) greenhouse gases into fuels and chemicals are vital for the biosustainability of future industries. Acetogens are the most efficient known microbes for fixing carbon oxides CO2 and CO. Understanding proteome allocation is important for metabolic engineering ...
ORGANISM(S): Clostridium autoethanogenum 
2022-05-22 | PXD025732 | Pride
Absolute quantification  acetogen  gas fermentation  data-independent acquisition  dia 
TranscriptomicsSpecific growth rate dependent transcriptome profiling of Escherichia coli K12 MG1655 in accelerostat cultures
Specific growth rate dependent gene expression changes of Escherichia coli K12 MG1655 were determined by microarray and real time PCR analyses. The bacteria were cultivated on glucose limited minimal medium using the accelerostat method (A-stat), where starting from steady state conditions in a chem...
ORGANISM(S): Escherichia coli 
2010-05-22 | E-GEOD-18183 | biostudies-arrayexpress
ProteomicsH2 drives metabolic rearrangements in gas-fermenting Clostridium autoethanogenum
Background: The global demand for affordable carbon has never been stronger, and there is an imperative in many industrial processes to use waste streams to make products. Gas-fermenting acetogens offer a potential solution and several commercial gas fermentation plants are currently under construct...
ORGANISM(S): Clostridium autoethanogenum 
2018-03-05 | PXD008367 | Pride
Acetogen  gas fermentation  quantitative proteomics  data-independent acquisition  genome-scale modelling  metabolomics 
ProteomicsA TetR-Family Protein (CAETHG_0459) Activates Transcription From a New Promoter Motif Associated With Essential Genes for Autotrophic Growth in Acetogens
Acetogens can fix carbon (CO or CO2) into acetyl-CoA via the Wood-Ljungdahl pathway (WLP) that also makes them attractive cell factories for the production of fuels and chemicals from waste feedstocks. Although most biochemical details of the WLP are well understood and systems-level characterisatio...
ORGANISM(S): Clostridium autoethanogenum 
2019-11-20 | PXD014421 | Pride
Biological  data-dependent acquisition  gas fermentation  acetogen 
OtherProteome reallocation in Escherichia coli with increasing specific growth rate
Data from ProteomeXchange, PXD ID: PXD001594. File: 130326_01_Orbi1_SK_SER_G250_T295_Piimhappe_BT_projekt_proov_F201_S2_P9.mzml. Published as part of Mol Biosyst. 2015 Feb 25 . From ProteomeXchange: {{i}} E. coli was grown on minimal and defined rich media in steady state continuous cultures at dif...
ORGANISM(S): Enterobacteria_phage_13a_uid30603, Enterobacteria_phage_933w_uid14043, Enterobacteria_phage_alpha3_uid14570, Enterobacteria_phage_ba14_uid30599, Enterobacteria_phage_bp_4795_uid14287, Enterobacteria_phage_bz13_uid14635, Enterobacteria_phage_cdti_uid19737, Enterobacteria_phage_ecods1_uid30601, Enterobacteria_phage_eps7_uid29287, Enterobacteria_phage_epsilon15_uid14285, Enterobacteria_phage_es18_uid15174, Enterobacteria_phage_felix_01_uid14323, Enterobacteria_phage_fels_2_uid32273, Enterobacteria_phage_fi_sensu_lato_uid15459, Enterobacteria_phage_g4_sensu_lato_uid14318, Enterobacteria_phage_hk022_uid14048, Enterobacteria_phage_hk620_uid14115, Enterobacteria_phage_hk97_uid14592, Enterobacteria_phage_i2_2_uid14572, Enterobacteria_phage_id18_sensu_lato_uid16628, Enterobacteria_phage_id2_moscow_id_2001_uid16591, Enterobacteria_phage_if1_uid14039, Enterobacteria_phage_ike_uid14627, Enterobacteria_phage_ime08_uid50177, Enterobacteria_phage_jk06_uid15569, Enterobacteria_phage_js10_uid38265, Enterobacteria_phage_js98_uid27983, Enterobacteria_phage_jse_uid38263, Enterobacteria_phage_k1e_uid16228, Enterobacteria_phage_k1f_uid15880, Enterobacteria_phage_k1_5_uid17059, Enterobacteria_phage_lambda_uid14204, Enterobacteria_phage_m13_uid14549, Enterobacteria_phage_min27_uid29143, Enterobacteria_phage_ms2_uid14659, Enterobacteria_phage_mu_uid14105, Enterobacteria_phage_n15_uid14086, Enterobacteria_phage_n4_uid18511, Enterobacteria_phage_p1_uid14493, Enterobacteria_phage_p22_uid14478, Enterobacteria_phage_p2_uid14035, Enterobacteria_phage_p4_uid14414, Enterobacteria_phage_phi1_uid20789, Enterobacteria_phage_phieco32_uid28729, Enterobacteria_phage_phiecom_gj1_uid27979, Enterobacteria_phage_phip27_uid14599, Enterobacteria_phage_phiv10_uid16381, Enterobacteria_phage_phix174_sensu_lato_uid14015, Enterobacteria_phage_prd1_uid14062, Enterobacteria_phage_psp3_uid14345, Enterobacteria_phage_rb14_uid37825, Enterobacteria_phage_rb16_uid51699, Enterobacteria_phage_rb32_uid17997, Enterobacteria_phage_rb43_uid15417, Enterobacteria_phage_rb49_uid14301, Enterobacteria_phage_rb51_uid37819, Enterobacteria_phage_rb69_uid15141, Enterobacteria_phage_rtp_uid16178, Enterobacteria_phage_sf6_uid14498, Enterobacteria_phage_sfv_uid14162, Enterobacteria_phage_sp6_uid14291, Enterobacteria_phage_ssl_2009a_uid34919, Enterobacteria_phage_st104_uid14499, Enterobacteria_phage_st64t_uid14230, Enterobacteria_phage_st_1_uid38669, Enterobacteria_phage_t1_uid14496, Enterobacteria_phage_t3_uid14336, Enterobacteria_phage_t4_uid14044, Enterobacteria_phage_t5_uid15143, Enterobacteria_phage_t7_uid14460, Enterobacteria_phage_tls_uid19775, Enterobacteria_phage_vt2_sakai_uid14480, Enterobacteria_phage_wa13_sensu_lato_uid16595, Enterobacteria_phage_wv8_uid38281, Enterobacteria_phage_yyz_2008_uid32231, Enterobacteriophage_qbeta_uid15479, Escherichia_coli_k_12_substr__dh10b, Escherichia_coli_k_12_substr__mg1655 
GPM32320007851 | GPMDB
Resource Reanalysis 
TranscriptomicsSystems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase
Background: The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts val...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-09-02 | E-GEOD-23920 | biostudies-arrayexpress
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