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TranscriptomicsAnalysis of the Heat Shock Response in Mouse Liver Reveals Transcriptional Dependence on the Nuclear Receptor PPARα
The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) regulates responses to chemical or physical stress in part by altering expression of genes involved in proteome maintenance. Many of these genes are also transcriptionally regulated by heat shock (HS) through activation ...
ORGANISM(S): Mus musculus 
2009-05-01 | E-GEOD-14869 | biostudies-arrayexpress
TranscriptomicsHepatic xenobiotic metabolizing enzyme gene expression through the life stages of the mouse
Using full-genome arrays, the expression of all XMEs was examined during fetal (gestation day (GD) 19), neonatal (postnatal day (PND) 7), prepubescent (PND30), middle age (12 mon), and old age (18 and 24 mon) in the C57Bl6/J mouse liver and compared to young adults. Fetal and neonatal life stages h...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21716 | biostudies-arrayexpress
TranscriptomicsTranscriptional ontogeny of the developing liver
We characterized gene expression changes in the developing mouse liver at gestational days (GD) 11.5, 12.5, 13.5, 14.5, 16.5, and 19.5 and in the neonate (postnatal day (PND) 7 and 30) using full-genome microarrays and compared these changes to that in the adult liver. The fetal liver, and to a less...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21224 | biostudies-arrayexpress
TranscriptomicsTumorigenic carryover effects of early life exposure to dichloroacetic acid in male B6C3F1 mice
Here we investigated the longterm carryover effects of dichloroacetic acid (DCA), a common by-product of drinking water chlorination, on hepatic tumorigenesis in mice. Our findings demonstrate that postnatal exposure to a common drinking water contaminant results in longterm carryover effects on tum...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-58585 | biostudies-arrayexpress
TranscriptomicsInhaled Ozone (O3)-Induces Changes in Serum Metabolomic and Liver Transcriptomic Profiles in Rats
Long-term exposure to particulate air pollutants has been linked to increased incidence of Type 2 Diabetes (T2DM). Recently, we showed that the gaseous pollutant, O3, induced glucose intolerance, and increased serum leptin and epinephrine in Brown Norway rats. In this study, we hypothesized that O3 ...
ORGANISM(S): Rattus norvegicus 
2015-01-31 | E-GEOD-59329 | biostudies-arrayexpress
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