Sort   by:  
 Page size 
ProteomicsA chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase
Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibitors. Their catalytic domains are druggable, but these are shared or very similar between individual phosphatase complexes, precluding their specific inhibition. Instead, phosphatase complexes achieve ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD056390 | Pride
Phosphoproteomics Phosphatase Phosphorylation Pp2a-b56 
ProteomicsIdentification of ischemia-reperfusion induced protein changes in human intestine using quantitative (phospho)proteomics and MALDI mass spectrometry imaging
Intestinal ischemia-reperfusion injury (IR) is a severe clinical condition, and unraveling its pathophysiology is crucial in order to improve therapeutic strategies and reduce the high morbidity and mortality rates. Here, we studied the dynamic proteome and phosphoproteome in human intestine during ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD026076 | Pride
Intestine Reperfusion Phosphoproteomics Ischemia 
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
PXD026088 | panorama
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
Unknown2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis.
Not available
S-EPMC7755424 | biostudies-literature
UnknownThe Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial.
Not available
S-EPMC6974741 | biostudies-literature
UnknownEffectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial.
Not available
S-EPMC9178530 | biostudies-literature
UnknownImpact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry.
Not available
S-EPMC11882944 | biostudies-literature
UnknownA Paleogenomic Reconstruction of the Deep Population History of the Andes.
Not available
S-EPMC7304944 | biostudies-literature
Sort   by:  
 Page size