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ProteomicsHDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
TDP-43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP-43, are one of the common causes of familial ALS. In this study, we investigate TDP-43 prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-15 | PXD023852 | Pride
Induced pluripotent stem cells Axonal transport Tdp-43 Als Tardpb mutation Hdac6 Interactome 
Genomicsena-DATASET-TAGC-18-03-2014-13:20:29:283-320 - samples
Whole genome, high coverage, sequencing of 128 Ashkenazi Jewish controls
EGAD00001000781 | EGA
GenomicsWhole-Genome Sequencing of 128 Ashkenazi Jewish individuals
We sequenced 128 individuals of Ashkenazi Jewish ancestry. All individuals were controls in other studies: (1) Longevity (Gil Atzmon's lab; Albert Einstein College of Medicine), n=74. (2) Parkinson's disease (Lorraine Clark's lab; Columbia University Medical Center), n=54. Whole-genome, high-cover...
EGAS00001000664 | EGA
GenomicsThe Ashkenazi Genome Consortium Data Access Committee
Data Access Committee EGAC00001000151
EGAC00001000151 | EGA
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