Sort   by:  
 Page size 
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
UnknownSARS-CoV-2 Spike S1-specific IgG kinetic profiles following mRNA or vector-based vaccination in the general Dutch population show distinct kinetics.
Not available
S-EPMC8990276 | biostudies-literature
TranscriptomicsGene expression alteration by macrophage depletion in IKKα mutant mice
We generated Ikkα-KA/KA knock-in mice (KA/KA), in which an ATP binding site of Ikkα Lys 44 was replaced by alanine. The knock-in mice develop severe skin lesions and begin to die after 6 to 10 months. We also found lung SCCs in some of the mice. To study lung SCC development, we stabilize the skin c...
ORGANISM(S): Mus musculus 
2012-05-01 | GSE37655 | GEO
TranscriptomicsGene expression alteration by macrophage depletion in IKKα mutant mice
We generated Ikkα-KA/KA knock-in mice (KA/KA), in which an ATP binding site of Ikkα Lys 44 was replaced by alanine. The knock-in mice develop severe skin lesions and begin to die after 6 to 10 months. We also found lung SCCs in some of the mice. To study lung SCC development, we stabilize the skin c...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-37655 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile in the colon in response to C. rodentium infection.
The identification of Atg16L1 as a susceptibility gene has implicated antibacterial autophagy in the pathogenesis of Crohn's disease, a major type of inflammatory bowel disease (IBD). However, the role of Atg16L1 during extracellular bacterial infections of the intestine has not been sufficiently ex...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-49109 | biostudies-arrayexpress
UnknownLack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.
Not available
S-EPMC1949343 | biostudies-literature
TranscriptomicsConditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis
This study investigates the role of ADAM17 (a disintegrin and metalloproteinase 17) in skin homeostasis. Here, we show that mice lacking ADAM17 in keratinocytes have a normal epidermal barrier and skin architecture at birth, but develop pronounced defects in epidermal barrier integrity soon after bi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-38830 | biostudies-arrayexpress
UnknownLatent classes of sexual risk and corresponding STI and HIV positivity among MSM attending centres for sexual health in the Netherlands.
Not available
S-EPMC7029242 | biostudies-literature
UnknownCD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Not available
S-EPMC2923071 | biostudies-literature
UnknownRequirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.
Not available
S-EPMC2951380 | biostudies-literature
Sort   by:  
 Page size