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TranscriptomicsHuman pancreatic adenocarcinoma contains a side population resistant to gemcitabine
BACKGROUND: Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. Our aim was to search...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-36563 | biostudies-arrayexpress
TranscriptomicsMolecular markers associated with outcome and metastasis in human pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-42952 | biostudies-arrayexpress
TranscriptomicsThe side population of human pancreatic cancer expresses cancer stem cell-associated genes
Purpose: To explore the side population (SP) in pancreatic ductal adenocarcinoma (PDAC) for its gene expression profile and its association to cancer stem cells (CSC) and to evaluate the value of genes from its gene signature on patient survival. Experimental design: Side and main population (MP) c...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-42404 | biostudies-arrayexpress
TranscriptomicsSide population cells in human primary melanoma
Melanoma remains the most lethal skin cancer, mainly because of high resistance to therapy. Side population (SP) cells are found in many types of cancer and are usually enriched in therapy-resistant as well as tumorigenic cells. Here, we identified a Hoechst dye-effluxing SP in a large series of hum...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-48838 | biostudies-arrayexpress
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