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MetabolomicsMulti-Omics Elucidation of Cyclic Lipopeptide Pseudodesmin A-Mediated Biofilm eradication in Vancomycin-Resistant Enterococcus faecalis
In this study, we isolated and purified cyclic lipopeptide PDMA from our in-house strain Pseudomonas tolaasii ZTB4. We evaluated its antibacterial and antibiofilm activities against VREF, demonstrating that PDMA effectively eradicates mature biofilms. To decipher the mechanisms underlying this eradi...
2026-06-05 | MTBLS14677 | MetaboLights
ProteomicsThe functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureu
Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance in poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; ...
ORGANISM(S): Staphylococcus aureus 
2024-03-18 | PXD049022 | Pride
Staphylococcus aureus Vancomycin tolerance 
TranscriptomicsResponse of Streptomyces coelicolor to treatment with the antibiotics vancomycin bacitracin and moenomycin A
To determine the response at the transcriptional level of S. coelicolor cells to treatment with 3 antibiotics that target distinct stages of cell wall biosynthesis, biological triplicate cultures of strain M600 were treated with sub-lethal concentrations (10 µg/ml) of vancomycin, bacitracin or moeno...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2011-04-29 | E-MEXP-3032 | biostudies-arrayexpress
UnknownTranscriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae.
Not available
S-EPMC5494751 | biostudies-literature
UnknownIn Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to Vancomycin.
Not available
S-EPMC5278750 | biostudies-literature
OtherThe functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureus [Ribo-seq]
Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance in poorly understood. ...
ORGANISM(S): Staphylococcus aureus subsp. aureus str. JKD6008 
2024-03-18 | GSE254531 | GEO
TranscriptomicsThe functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureus [RNA-seq]
Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance in poorly understood. ...
ORGANISM(S): Staphylococcus aureus subsp. aureus str. JKD6008 
2024-03-18 | GSE254530 | GEO
OtherThe functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureus [RNase III-CLASH]
Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance in poorly understood. ...
ORGANISM(S): Staphylococcus aureus subsp. aureus str. JKD6008 
2024-03-18 | GSE254532 | GEO
ProteomicsRestriction of Arginine Induces Antibiotic Tolerance in Staphylococcus aureus
Staphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment. Antibiotic tolerance, the ability of bacteria to persist despite normally lethal doses of antibi...
ORGANISM(S): Staphylococcus aureus 
2024-07-11 | PXD052440 | Pride
Proteomics Skin and soft tissue infection (ssti) Biofilm Antibiotic treatment failure Tnseq Protein synthesis Staphylococcus aureus 
GenomicsThe functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureus [RNA-seq]
The functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin tolerant Staphylococcus aureus [RNA-seq]
PRJNA1070979 | ENA
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