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MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
UnknownA critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free fatty acids. The mechanism upstream of this PPARα downregulat...
S-SCDT-10_1038-S44321-024-00130-1 | biostudies-other
UnknownReprogramming of glucocorticoid receptor function by hypoxia
Here, we investigate the impact of hypoxia on the hepatic response of glucocorticoid receptor (GR) to dexamethasone (DEX) in mice via RNA-sequencing. Hypoxia causes three types of reprogramming of GR: (i) much weaker induction of classical GR response genes by DEX in hypoxia (ii) a number of genes i...
S-SCDT-EMBOR-2021-53083-T | biostudies-other
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