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Lymph node involvement is the most important prognostic factor in breast cancer, but little is known about the underlying molecular changes. First, to identify a molecular signature associated with nodal metastasis, gene expression analysis was performed on a homogeneous group of 96 primary breast t...
ORGANISM(S): Homo sapiens 
Endocytosis controls the perception of stimuli by modulating protein abundance at the plasma membrane. In plants, clathrin-mediated endocytosis is the most prominent internalization pathway and relies on two multimeric adaptor complexes, the AP-2 and the TPLATE complex (TPC). Ubiquitination is a wel...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-03-11 | PXD035444 | Pride
Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-03-04 | PXD023051 | Pride
Clathrin-mediated endocytosis is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form membrane-bound vesicles. The evolutionarily ancient TSET/TPLATE complex (TPC) plays an essential, but not well-defined role in endocytosis in plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-12-07 | PXD045068 | Pride
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