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TranscriptomicsGenome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors
Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cel...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
TranscriptomicsIllumina Human1Mv1_C array CGH on NCI-60 cancer cell lines
The NCI-60 cancer cell lines have been used for studying cancer pathogenesis and for drug discovery. This dataset adds to the growing number of datasets on various genomic platforms that have been made public on Cellminer (http://discover.nci.nih.gov/cellminer/) 60 cell lines (including PR:DU145 and...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-47620 | biostudies-arrayexpress
TranscriptomicsAgilent-013282 array CGH on NCI-60 cancer cell lines
The NCI-60 cancer cell lines have been used for studying cancer pathogenesis and for drug discovery. This dataset adds to the growing number of datasets on various genomic platforms that have been made public on Cellminer (http://discover.nci.nih.gov/cellminer/) 60 cell lines (including PR:DU145 and...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-48568 | biostudies-arrayexpress
TranscriptomicsComparison between cell lines from 9 different cancer tissue (NCI-60) (Affymetrix U133 Plus 2.0)
Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel. Cell lines from 9 different cancer tissue of origin types
ORGANISM(S): Homo sapiens 
2011-09-28 | E-GEOD-32474 | biostudies-arrayexpress
TranscriptomicsClinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions
The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient s...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-29702 | biostudies-arrayexpress
TranscriptomicsMurine lung transcripts during soluble egg antigen (SEA)-induced allergic asthma and bleomycin-induced pulmonary fibrosis in Wildtype, IL-13Ra1 and IL-13Ra2 deficient mice sensitized and challenged
Transcriptional profiling of mouse lungs by comparing PBS and saline treated lungs with SEA and bleomycin treated lungs, respectively. Mice strains used in this study include wild type (C57BL/6), IL-13Ra1 and IL-13Ra2 deficient mice. In mouse model of allergic asthma, mice were sensitized twice (day...
ORGANISM(S): Mus musculus 
2011-09-06 | E-GEOD-27721 | biostudies-arrayexpress
TranscriptomicsComparison between cell lines from 9 different cancer tissue (NCI-60) (Affymetrix HuEx 1.0)
Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Cell lines from 9 different cancer tissue of origin types
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29682 | biostudies-arrayexpress
TranscriptomicsIndividual multidrug resistance patterns in AML patients point to the need for personalized molecular analysis
In this unique study, based on paired samples obtained at AML diagnosis and at relapse, we assessed 380 multidrug-resistance-related genes, using TaqMan-based qRT-PCR, as indicated by reports published over the past three decades. 11 paired AML samples taken at diagnosis and at relapse after treatme...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-33787 | biostudies-arrayexpress
TranscriptomicsMultidrug Resistance-Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma
This study assesses the ability of multidrug resistance (MDR)-associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large set of genes was evaluated wh...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-30009 | biostudies-arrayexpress
TranscriptomicsComparison between cell lines from 9 different cancer tissue (NCI-60) (Agilent WG platform)
Comparison between cell lines from 9 different cancer tissue of origin types Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel
ORGANISM(S): Homo sapiens 
2011-06-12 | E-GEOD-29288 | biostudies-arrayexpress
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