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TranscriptomicsHormonal and epigenetic control of hematopoiesis
To study the role of epigenetics and hormones on hematopoietic stem cell function, hematopoietic stem and progenitor (LSK) cells were sorted from E14.5 embryos of wild-type, DNMT3B7 hemizygous or DNMT3B7 homozygous genotype. The expression analysis was performed to provide information regarding the ...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-56170 | biostudies-arrayexpress
GenomicsHydroxymethylation at gene regulatory regions directs stem cell commitment during erythropoiesis
CD34 positive hematopoietic stem cells were differentiated into erythroid lineage. Next generation sequencing (NGS) of 5hmC affinity pulldown and RNAseq were performed in four time point of different stages of erythroid differentiation. 4 RNA-Seq Samples (d0, d3, d7 and d10); 4 affinity-pulldown (d...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-40243 | biostudies-arrayexpress
Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
TranscriptomicsTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Recurrent somatic mutations in TET2 and in other genes that regulate the epigenetic state have been identified in patients with myeloid malignancies and in other cancers. However, the in vivo effects of Tet2 loss have not been delineated. We report here that Tet2 loss leads to increased stem-cell...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-27816 | biostudies-arrayexpress
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