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TranscriptomicsAffymetrix gene expression array (mouse 2.0) of sorted undifferentiated spermatogonia in inducible Miwi2 knock-out model
Undifferentiated spermatogonia were sorted from Miwi2Tom/FL; ERT-Cre/+ (Miwi2-iKO) and Miwi2Tom/+; ERT-Cre/+ (Miwi2-CTL) mice injected with tamoxifen two weeks after last tamoxifen injection to understand an impact of acute Miwi2 deletion on spermatogenic homeostasis.
ORGANISM(S): Mus musculus 
2018-03-21 | E-MTAB-6612 | biostudies-arrayexpress
TranscriptomicsMelanoma experimental metastasis model
Application of a melanoma experimental metastasis model to elucidate molecular mediators of melanoma brain metastasis. Malignant melanoma frequently metastasizes to the brain. The molecular mediators of brain metastasis still remains largely unknnown. Two melanoma cell lines (opposing phenotypes in ...
ORGANISM(S): Homo sapiens 
2014-02-26 | E-MTAB-2065 | biostudies-arrayexpress
TranscriptomicsMultiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis
The Piwi protein Mili and the Piwi-interacting RNA (piRNA) pathway are required to establish L1 DNA methylation during epigenetic reprogramming that accompanies male germ cell development. Although Mili is expressed throughout most of adult spermatogenesis, its function therein remains unknown. We f...
ORGANISM(S): Mus musculus 
2013-07-03 | E-MTAB-1557 | biostudies-arrayexpress
TranscriptomicsEffect of extracellular S100A4 on melanoma cells of different phenotypes
S100A4 is a known metastasis-promoting factor, rich in the tumor microenvironment. To clarify how extracellular S100A4 execute its pro-metastatic function, we analyzed gene expression in melanoma cells stimulated with recombinant protein rS100A4 and compared it to the expression in control non-stimu...
ORGANISM(S): Homo sapiens 
2015-02-13 | E-GEOD-65897 | biostudies-arrayexpress
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