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TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
UnknownKnockdown of TP53 in ASXL1 negative background rescues apoptotic phenotype of human hematopoietic stem and progenitor cells but without overt malignant transformation.
Not available
S-EPMC5792287 | biostudies-literature
GenomicsOncofusion protein AML1-ETO targets ERG factor binding sites in AML
ERG has been identified as an essential factor for the function and maintenance of adult hematopoietic stem cells and high ERG expression is a negative prognostic marker for treatment outcome in AML. The molecular function of ERG and its interplay with other factors is however largely unknown. Here ...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-23730 | biostudies-arrayexpress
UnknownELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.
Not available
S-EPMC4216115 | biostudies-literature
UnknownConvergence of hypoxia and TGFβ pathways on cell cycle regulation in human hematopoietic stem/progenitor cells.
Not available
S-EPMC3970968 | biostudies-literature
UnknownMaximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels.
Not available
S-EPMC2573230 | biostudies-literature
UnknownDasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases.
Not available
S-EPMC2908401 | biostudies-literature
UnknownDeterminants of lenalidomide response with or without erythropoiesis-stimulating agents in myelodysplastic syndromes: the HOVON89 trial.
Not available
S-EPMC10997501 | biostudies-literature
TranscriptomicsIdentification of STAT5 target genes in human CB HSC, CMP, GMP and MEP
CB CD34+ cells were isolated by Miltenyi miniMACS column. Cells were prestimulated in HPGM with 100 ng/ml KITL, FLT#L and TPO for 48 hrs. Cells were transduced with control MiNR1 or STAT5A-ER in three rounds over 48 hrs. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), granulocyte...
ORGANISM(S): Homo sapiens 
2011-01-22 | E-GEOD-26775 | biostudies-arrayexpress
UnknownCombined HAT/EZH2 modulation leads to cancer-selective cell death.
Not available
S-EPMC5986654 | biostudies-literature
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