Sort   by:  
 Page size 
TranscriptomicsMolecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded p...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26604 | biostudies-arrayexpress
TranscriptomicsVastus lateralis muscle aging
Development of a method to identify age-regulated expression trends in skeletql muscles and study the underlying molecular processes of the age_associated progressive changes in skeletal muscles. See abstract from associated manuscript below : Aging is characterized by progressive tissue degenerat...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-40645 | biostudies-arrayexpress
TranscriptomicsModeling OPMD in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein
Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease caused by an alanine tract expansion mutation in Poly(A)-binding protein nuclear 1 (expPABPN1). To model OPMD in a myogenic and physiological context, we generated mouse myoblast cell clones stably expressing either human wil...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29909 | biostudies-arrayexpress
Sort   by:  
 Page size