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TranscriptomicsChromosomal abberations and transcriptional characteristics linked to the pathogenesis of diffuse large b-cell lymphomas
We superimposed array comparative genomic hybridization (aCGH) data onto existing expression array profiles (GSE3892) to sift out the pivotal genes underlying the pathogenesis of a well defined series of diffuse large B-cell lymphomas (DLBCL). 280 gained and over-expressed genes were identified, loc...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-5138 | biostudies-arrayexpress
TranscriptomicsInvestigation of somatic copy number variation in MZ twins
There is growing evidence that genomic DNA sequence changes occur in individual somatic cells during the lifetime of an individual and accumulation of these changes may influence aging and disease. In light of this, and contradicting reports regarding discordant copy number profiles between MZ twins...
ORGANISM(S): Homo sapiens 
2010-12-11 | E-GEOD-25826 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for acute lymphoblastic leukemia and lymphoblastic lymphoma samples
Childhood T-cell malignancies include T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). T-ALL and T-LBL share common morphologic and immunophenotypic features and are treated with similar therapeutic approaches. Nonetheless, they show distinct clinical presenta...
ORGANISM(S): Homo sapiens 
2012-06-29 | E-GEOD-30319 | biostudies-arrayexpress
TranscriptomicsHDACI and DAC induce specific epigenetic profile in DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoid neoplasm in the world representing 30-40% of all lymphomas. Standard immunochemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) ensures cure in 60 to 65% of patients, while the rest progress or r...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-27226 | biostudies-arrayexpress
TranscriptomicsTranscription profiling twenty eight growth restricted patients (including twenty two with Silver-Russel syndrome) and their parents
We studied twenty-eight growth restricted patients (twenty-two with Silver-Russell syndrome, OMIM#180860) and their parents with the Affymetrix 250K Sty SNP microarray. All patients were molecularly undefined, and thus the aim was to look for copy number alterations that might contribute to the grow...
ORGANISM(S): Homo sapiens 
2009-09-06 | E-MTAB-56 | biostudies-arrayexpress
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
TranscriptomicsRepresentational Oligonucleotide Microarray Analysis (ROMA) array for Copy Number Variation Detection.
The identification of genetic and epigenetic alterations from primary tumor cells has become a common method to identify genes critical to the development and progression of cancer. We provide a bioinformatic analysis of copy number variation and DNA methylation covering the genetic landscape of ova...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-28013 | biostudies-arrayexpress
TranscriptomicsIdentification of Tumor Suppressors and Oncogenes from Genomic and Epigenetic Features in Ovarian Cancer
This SuperSeries is composed of the following subset Series: GSE27940: Methylation detection Oligonucleotide Microarray Analysis: high resolution method for CpG island methylation detection 3. GSE27943: Gene Expression Array of Human Ovarian Cancer. GSE28013: Representational Oligonucleotide Microar...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-28015 | biostudies-arrayexpress
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
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