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Genomicsena-DATASET-DKFZ-HIPO-04-02-2020-14:25:47:776-113 - samples
This dataset contains 3 pairs of exomes, germline (from whole blood) and patient-derived xenograft (PDX), from human pancreatic durctal adenocarcinoma patients. The data is referred to in the publication: "Pro-immunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory a...
EGAD00001005938 | EGA
Genomicspancreatic ductal adenocarcinoma exomes in study: Pro-immunogenic Impact of MEK inhibition combined with an anti-CD40 immunostimulatory antibody
Cancer types with lower mutational load and a non-permissive tumor microenvironment are intrinsically resistant to immune checkpoint blockade. While the combination of cytostatic drugs and immunostimulatory antibodies constitutes an attractive concept for overcoming this refractoriness, suppression ...
EGAS00001004196 | EGA
TranscriptomicsMulti-level omics analysis of gene expression in a murine model of dystrophin loss and therapeutic restoration [mRNA]
Duchenne muscular dystrophy (DMD) is a classical monogenic disorder, a model disease for genomic studies and a priority candidate for regenerative medicine and gene therapy. Although the genetic cause of DMD is well known, the molecular pathogenesis of disease and the response to therapy are incompl...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-64418 | biostudies-arrayexpress
TranscriptomicsMulti-level omics analysis of dystrophin loss and therapeutic restoration in a murine model [microRNA]
Duchenne muscular dystrophy (DMD) is a classical monogenic disorder, a model disease for genomic studies and a priority candidate for regenerative medicine and gene therapy. Although the genetic cause of DMD is well known, the molecular pathogenesis of disease and the response to therapy are incompl...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-64419 | biostudies-arrayexpress
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