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TranscriptomicsZbtb16 Has a Role in Brown Adipocyte Bioenergetics
Study designed to identify genes that are induced in both BAT and skeletal muscle during acute adaptive thermogenesis in mouse using gene expression microarray. Animal studies were performed under approved UCLA animal research protocols and according to guidelines established in the Guide for Care ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-40486 | biostudies-arrayexpress
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
TranscriptomicsEvidence of mechanism how rs7575840 influences apolipoprotein B containing lipid particles
Objective: Recent genome-wide association studies (GWAS) identified a variant rs7575840 in the apolipoprotein B (APOB) gene region to be associated with LDL-C. However, the underlying functional mechanism of this variant that resides 6.5 kb upstream of APOB has remained unknown. Our objective was to...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-27666 | biostudies-arrayexpress
TranscriptomicsLimiting cholesterol biosynthetic flux engages type I IFN signaling in a STING-dependent manner
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling rapidly shifts the balance of these programs by decreasing synthesis and increasing import of cholesterol and long chain f...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-73942 | biostudies-arrayexpress
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