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GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
GenomicsGenome wide association study for Bladder Cancer Risk

This study funded by the National Cancer Institute (NCI) involves conducting a genome-wide association study of common genetic variants to identify markers of susceptibility to bladder cancer.

This bladder GWAS has led to the discovery of three novel regions in the genome associated with...

phs000346.v1.p1 | EGA
TranscriptomicsLoss of ZEB2 in basal breast cancer cells
Study of loss of ZEB2 in breast cancer cells in vitro and in vivo: gene expression and phenotypic switch to more benign behavior of the cancer cells. Morphological, functional and gene microarray analysis following ZEB2 knockdown in MDAMB231 cells reveals gain of epithelial differentiation, reductio...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-27966 | biostudies-arrayexpress
TranscriptomicsOncogenic Activation Of FOXR1 by 11q23 Intrachromosomal Deletion-Fusions In Neuroblastoma
Neuroblastoma tumors frequently show loss of heterozygosity of chromosome 11q with a shortest region of overlap in the 11q23 region. These deletions are thought to cause inactivation of tumor suppressor genes leading to haploinsufficiency. Alternatively, micro-deletions could lead to gene fusion p...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-29634 | biostudies-arrayexpress
UnknownPolymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.
Not available
S-EPMC3103497 | biostudies-literature
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
GenomicsBreast Cancer Histology Images
Fresh frozen breast cancer H&E tissue images collected and annotated by the International Cancer Genome Consortium (ICGC), that included the BASIS collaboration. Associated with whole genome sequence data as originally described by Nik-Zainal et al, Nature, 2016 (DOI: 10.1038/nature17676) and de...
EGAD00010001911 | EGA
UnknownImputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Not available
S-EPMC4240198 | biostudies-literature
TranscriptomicsTGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [organoids]
The aim of this study was to determine the effects of TGFβ at the premalignant stage of CRC development. Organoid cultures were isolated from normal colon and from tubular adenomas. One normal colon culture was genetically engineered using the CRISPR-Cas9 system to carry the BRAFV600E mutation. Org...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79461 | biostudies-arrayexpress
TranscriptomicsTGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas]
Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to deter...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79460 | biostudies-arrayexpress
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