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ProteomicsHuman sepsis with plasma samples
The project examines the mechanisms of neutrophil dysfunction during sepsis. Our work uncovered the central role of cell free circulating histones in eliminating mature neutrophil in favour of immature cells and characterized the mechanisms that regulate their release following systemic infection. M...
ORGANISM(S): Homo sapiens (Human) 
2022-07-01 | PXD034391 | Pride
Human plasma sepsis 
ProteomicsALSPAC human inflammation plasma proteomics
The project aimed at investigating the impact of chronic low grade inflammation on plasma functions and plasma proteomes in healthy individuals.
ORGANISM(S): Homo sapiens (Human) 
2022-11-26 | PXD037682 | Pride
Proteomics Avon longitudinal study of parents and children – alspac Inflammation Human Plasma 
ProteomicsPlasma proteomics in mouse sepsis
Analysis of plasma proteomes from 8 week old C57BL/6J WT or TCRα-/- (Tcratm1Phi) either naïve or infected by intravenous injection of 5x105 yeast (clinical isolate SC5314), and collected 72 hrs post-infection
ORGANISM(S): Mus musculus (Mouse) 
2022-11-26 | PXD037676 | Pride
Mice  plasma  proteomics  sepsis 
ProteomicsRapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens (Human) 
2025-09-03 | PXD061797 | Pride
Mrna degradation Nmd Gene expression Nonsense-mediated mrna decay Upf1 Translation 
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