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TranscriptomicsTranscription profiling of human colorectal cancer samples with CpG island methylator phenotype (CIMP)
The CpG island methylator phenotype (CIMP) in colorectal tumors can be recognized by an increased frequency of aberrant methylation in a specific set of genomic loci. Because of the strong association of CIMP with high microsatellite instability (MSI-H), the identification of CIMP+ tumors within mi...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-TABM-328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood from chronic lymphocytic leukemia patients before and after Fludarabine treatment
Transcription profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-825 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
Molecular profile of Fludarabine refractory and sensitive CLLs
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-824 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human colorectal cancer samples with high microsatellite instability
Background. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results. We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H)...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-TABM-326 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of peripheral blood mononuclear cells from CLL patients to identify a signature for specific chromasomal abnormalities (OSU-CCC microRNA array)
We studied the value of the microRNAs as a signature for CLL patients with specific chromosomal abnormalities. We identified 32 microRNAs able to discriminate the 11q deletion, 17p deletion, trisomy 12, and 13q deletion and normal karyotype cytogenetic subgroups. The expression values of 9 among the...
ORGANISM(S): Homo sapiens 
2009-10-01 | E-TABM-762 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cell lines and tissue samples to identify aberrant microRNA expression
MicroRNAs are a class of small non-coding RNAs that control gene expression by targeting messenger RNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, microRNA aberrant expression has been previo...
ORGANISM(S): Homo sapiens 
2006-01-01 | E-TABM-23 | biostudies-arrayexpress
TranscriptomicsmicroRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer (mouse)
MicroRNA deregulation is frequent in human colorectal cancers (CRCs) but little is known to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b over-expression is triggered in mouse and humans by APC loss, PTEN/PI3K pathway deregulation and by ...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-54177 | biostudies-arrayexpress
TranscriptomicsmicroRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer (Human cell line)
MicroRNA deregulation is frequent in human colorectal cancers (CRCs) but little is known to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b over-expression is triggered in mouse and humans by APC loss, PTEN/PI3K pathway deregulation and by ...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-54163 | biostudies-arrayexpress
TranscriptomicsIdentification of p53-regulated microRNAs in Hapatocellular Carcinoma (HCC).
p53 suppresses tumor progression and metastasis by regulating a large set of genes and microRNAs. By profiling 92 primary hepatocellular carcinomas (HCCs) and 9 HCC cell lines, we found that p53 upregulates microRNAs including miR-200 and miR-192 family members. By sequencing TP53 in 92 HCC samples,...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-28661 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human metastatic breast cancer
metastatic breast cancer miRNA
ORGANISM(S): Homo sapiens 
2010-06-02 | E-TABM-971 | biostudies-arrayexpress
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