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H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation
This submission contains the mass spectrometry files for the manuscript by Billon et al. that identified key lysines residues within PCNA that control its functions. This submission contains 16 .raw and 16.dta files where a gel band containing PCNA was analyzed as well as 2 scaffold files used for s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of RNA polymerase II, to prevent cryptic initiation within genes. Meth...
ORGANISM(S): Saccharomyces cerevisiae 
A Top2 and Hmo1-mediated genome architectural pathway preventing chromosome fragility.
Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple repeats of the heptapeptide YSPTSPS. Pioneering studies showed that CTD serines are differentially phosphorylated along...
ORGANISM(S): Saccharomyces cerevisiae 
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