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TranscriptomicsmRNA expression data of 62 human medulloblastoma tumors
To identify molecular subtypes of medulloblastoma we have profiled a series of 62 medulloblastoma tumors. Unsupervised hierarchical cluster analysis of these data identified 5 distinct molecular subtypes. Manuscript submitted. Title: Identification of medulloblastoma subtypes with distinct genetic p...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-10327 | biostudies-arrayexpress
TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
TranscriptomicsEffect of genomic imbalances on gene expression in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and resembles developing skeletal muscle. Specific genomic alterations including translocations, deletions and amplification events have been associated with the alveolar and embryonal subtypes of RMS. Characterizing these c...
ORGANISM(S): Homo sapiens 
2009-06-04 | E-GEOD-8840 | biostudies-arrayexpress
TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-16476 | biostudies-arrayexpress
UnknownmRNA expression data of 62 human medulloblastoma tumors
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-10327 | biostudies-other
TranscriptomicsNOTCH3 is a master-regulator of motility in neuroblastoma and is essential for cell survival
Migratory embryonal neuroblasts give rise to several tissues, including the sympathetic nervous system (SNS). Neuroblastomas are paediatric tumours of the peripheral SNS with a highly variable prognosis. We observed that high NOTCH3 expression in neuroblastomas correlated with a poor prognosis. Expr...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-16477 | biostudies-arrayexpress
TranscriptomicsIMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls.
IMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls. IMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls.
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-39218 | biostudies-arrayexpress
TranscriptomicsIn vitro expansion of human gastric epithelial stem cells and their primary response to bacterial infection
We previously established long-term 3D organoid culture systems for several murine tissues (intestine, stomach, pancreas and liver) as well as human intestine and pancreas. Here, we describe culture conditions to generate long-term 3D culture from human gastric stem cells. The technology can be appl...
ORGANISM(S): Homo sapiens 
2014-10-13 | E-GEOD-60557 | biostudies-arrayexpress
GenomicsAMC Dept. Oncogenomics
Data Access Committee EGAC00001000321
EGAC00001000321 | EGA
TranscriptomicsMethylation of Cancer Stem Cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients
This SuperSeries is composed of the following subset Series: GSE33112: Gene expression in colon cancer stem cells (CSC) cultures identified by Wnt signaling levels GSE33113: AMC colon cancer AJCCII Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-33114 | biostudies-arrayexpress
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