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TranscriptomicsPredicting response to vedolizumab therapy using mucosal transcriptomics in IBD patients
In this study we wanted to identify baseline predictors of successful vedolizumab therapy in patients with inflammatory bowel disease.
ORGANISM(S): Homo sapiens 
2019-08-23 | E-MTAB-7845 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of inflamed intestinal mucosa of inflammatory bowel disease patients
Studying differences in responders and non-responders to therapy in inflammatory bowel disease (IBD) patients (crohn's disease and ulcerative colitis)
ORGANISM(S): Homo sapiens 
2019-01-24 | E-MTAB-7604 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling predicting response to ustekinumab therapy in patients with Crohn's disease
This study aimed to identify a biomarker predicting response to ustekinumab therapy. Therefore, we used transcriptomic data (colonic and ileal tissue, CD4 T-cell and CD14 monocytes), which we integrated through Multi-Omics Factor Analysis.
ORGANISM(S): Homo sapiens 
2023-10-31 | E-MTAB-7799 | biostudies-arrayexpress
TranscriptomicsA multi-omics approach to understand and predict therapeutic success of anti-TNF and anti-integrin agents in inflammatory bowel disease
In this study we wanted to identify baseline predictors of successful anti-TNF and vedolizumab therapy in patients with inflammatory bowel disease (based on tissue transcriptomics and CD4/CD14 transcriptomics)
ORGANISM(S): Homo sapiens 
2023-10-31 | E-MTAB-7914 | biostudies-arrayexpress
TranscriptomicsRNA-seq of biopsies, crypts and organoids of inflamed and non-inflamed biopsies of ulcerative colitis patients
Patient-derived intestinal organoids provide an excellent tool to unravel mechanisms underlying ulcerative colitis (UC). Fresh biopsies, to isolate crypts and culture organoids, were obtained from both inflamed and non-inflamed regions from eight patients with active UC (Mayo endoscopic subscore ≥2)...
ORGANISM(S): Homo sapiens 
2020-10-08 | E-MTAB-7860 | biostudies-arrayexpress
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