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TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [RNA-Seq]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61066 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [gene expression]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61067 | biostudies-arrayexpress
TranscriptomicsAdenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs
We used transgenic mouse embryos that are deficient in the two enzymatically active RNA editing enzymes ADAR1 and ADAR2 to compare relative frequencies but also sequence composition of mature miRNAs in these genetically modified backgrounds to wild-type mice by Illumina next gen sequencing. Deficien...
ORGANISM(S): Mus musculus 
2012-02-02 | E-GEOD-34626 | biostudies-arrayexpress
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