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ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
ProteomicsExtrarenal ?-klotho expression in human tissues
?-Klotho has emerged as a powerful regulator of the ageing process. To-date, the expression profile of ?-Klotho in human tissues is unknown and its existence in some human tissue types is subject to much controversy. Objective: This is the first study to characterize system-wide tissue expression of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080719 | MassIVE
TranscriptomicsGene expression in wild type and mENT1 knock out mice
To investigate the functional importance of a nucleoside transporter, the mENT1 (Slc29a1) was knocked out in mice. The gene expression profile was compared between wildtype and mENT1 knock out mice in two tissues. RNA was isolated from heart and kidney from 3 mENT1 knockout and 3 wildtype (FVB/N) mi...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-22565 | biostudies-arrayexpress
MetabolomicsA Combined Metabolomic and Proteomic Investigation of the Effects of a Failure to Express Dystrophin in the Mouse Heart
Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. ...
2017-03-14 | MTBLS256 | MetaboLights
TranscriptomicsMGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib
Angiogenesis inhibitors, such as sunitinib, represent a promising strategy to improve glioblastoma (GBM) tumor response. In this study, we used the O6-methylguanine methyltransferase (MGMT)-negative GBM cell line U87MG stably transfected with MGMT (U87/MGMT) to assess whether MGMT expression affects...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40776 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes Grown at Refrigeration Temperature Shows Reduced Acid Survival and an Altered Transcriptional Response to Acid Shock
Survival of the foodborne pathogen Listeria monocytogenes in acidic environments (e.g., stomach and low pH foods) is vital to its transmission. L. monocytogenes grows at temperatures as low as 2M-BM-0C, and refrigerated, ready-to-eat foods have been sources of L. monocytogenes outbreaks. The purpose...
ORGANISM(S): Listeria monocytogenes 
2011-06-30 | E-GEOD-22672 | biostudies-arrayexpress
TranscriptomicsCharacterization of the SigB-PrfA regulatory network in Listeria monocytogenes
Listeria monocytogenes SigB and PrfA are pleiotropic regulators of stress response and virulence gene expression, which have been shown to co-regulate genes in L. monocytogenes. We performed whole genome transcriptional profiling in the presence of PrfA* and active SigB, to identify the overlaps be...
ORGANISM(S): Listeria monocytogenes 
2010-05-19 | E-GEOD-11347 | biostudies-arrayexpress
TranscriptomicsBrugia pahangi mature vs immature microfilariae
Filarial nematodes are arthropod-borne nematodes that cause a variety of economically important diseases such as onchocerciasis (river blindness), lymphatic filariasis, and heartworm disease. The most widespread filarial disease of humans is lymphatic filariasis, caused by worms in the genera Wuche...
ORGANISM(S): Brugia pahangi 
2010-05-22 | E-GEOD-14939 | biostudies-arrayexpress
TranscriptomicsBrugia malayi mature vs immature microfilariae
Filarial nematodes are arthropod-borne nematodes that cause a variety of economically important diseases such as onchocerciasis (river blindness), lymphatic filariasis, and heartworm disease. The most widespread filarial disease of humans is lymphatic filariasis, caused by worms in the genera Wuche...
ORGANISM(S): Brugia malayi 
2010-05-22 | E-GEOD-14940 | biostudies-arrayexpress
TranscriptomicsMature vs immature microfilariae
Filarial nematodes are arthropod-borne nematodes that cause a variety of economically important diseases such as onchocerciasis (river blindness), lymphatic filariasis, and heartworm disease. The most widespread filarial disease of humans is lymphatic filariasis, caused by worms in the genera Wuche...
ORGANISM(S): Brugia pahangi 
2009-10-01 | E-GEOD-15017 | biostudies-arrayexpress
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