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TranscriptomicsCellular adhesion promotes prostate cancer cells escape from dormancy
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, following initial treatment, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Iden...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-64262 | biostudies-arrayexpress
GenomicsOverexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-48308 | biostudies-arrayexpress
UnknownSrc promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.
Not available
S-EPMC5354662 | biostudies-literature
TranscriptomicsComparative analyses of chromosome alterations in metastases in castration-resistant prostate cancer patients
Androgen deprivation is the mainstay of therapy for progressive prostate cancer. Despite initial and dramatic tumor inhibition, most men eventually fail therapy and die of metastatic castration-resistant (CR) disease. Here, we characterize the profound degree of genomic alteration found in CR tumors...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-18259 | biostudies-arrayexpress
UnknownActivation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.
Not available
S-EPMC5395199 | biostudies-literature
TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
UnknownCellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy.
Not available
S-EPMC4475050 | biostudies-literature
UnknownCharacterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways.
Not available
S-EPMC4259449 | biostudies-literature
UnknownSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.
Not available
S-EPMC4609255 | biostudies-literature
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