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TranscriptomicsTranscription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endothelium of metastatic tumours has a distinct transcription profile.
Invasion of lymphatic vessels is a key step in the metastasis of primary tumour cells to draining lymph nodes. Recent evidence indicates that such metastasis can be facilitated by tumour lymphangiogenesis, although it remains unclear whether this is a consequence of increased lymphatic vessel number...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-6255 | biostudies-arrayexpress
TranscriptomicsVEGFR2 Y949F (lung RNAseq - mice)
RNA sequencing of lung tissue from transgenic mice in order to investigate the effect of a single tyrosine to phenylalanine exchange in the endothelial receptor VEGFR2 at position Y949. This exchange creates a mouse with unleaky blood vessels which is an advantage in several diseases such as cancer ...
ORGANISM(S): Mus musculus 
2020-06-12 | E-MTAB-9163 | biostudies-arrayexpress
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