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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsDifferential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.
Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose t...
ORGANISM(S): Mus musculus 
2012-03-22 | E-GEOD-36669 | biostudies-arrayexpress
UnknownGenomic and clinical features in young women with estrogen receptor-positive, HER2-negative breast cancer.
Not available
S-EPMC12495081 | biostudies-literature
TranscriptomicsGene expression profile of NAFLD murine models (Part1 - NGS)
In this project, the gene expression profiles of commonly used murine models of NAFLD were compared to two publically available human datasets to assess proximity to human pathophysiology, focusing on differential expression and pathway enrichment. CCL4 was used as a positive control for fibrosis.
ORGANISM(S): Mus musculus 
2024-03-18 | E-MTAB-12808 | biostudies-arrayexpress
UnknownLimited oxygen in standard cell culture alters metabolism and function of differentiated cells
Not available
S-SCDT-10_1038-S44318-024-00084-7 | biostudies-other
MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
UnknownCIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative.
Not available
S-EPMC9305285 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownTargeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial.
Not available
S-EPMC7786490 | biostudies-literature
UnknownEffect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
Not available
S-EPMC9073661 | biostudies-literature
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