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TranscriptomicsTranscriptomic Analysis of the Hippocampus from Six Inbred Strains of Mice Suggests Basis for Sex-Specific Susceptibility and Severity of Neurological Disorders
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioural disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease...
ORGANISM(S): Mus musculus 
2016-01-06 | E-GEOD-76567 | biostudies-arrayexpress
TranscriptomicsNucleosome Repositioning: Nicotine- and Cocaine-induced Changes
SH-SY5Y, neuroblastoma cells, were exposed to nicotine for 10, 60, and 90 minutes or cocaine for 5, 20, 40, and 60 minutes. Drugs of abuse modify behavior by altering gene expression in the brain. Gene expression can be regulated by changes in DNA methylation as well as by histone modifications, wh...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-71795 | biostudies-arrayexpress
TranscriptomicsA comprehensive examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period
The developmental transition to motherhood requires gene expression changes that alter the brain to prepare and drive the female to perform maternal behaviors. Furthermore, it is expected that the many physiological changes accompanying pregnancy and postpartum stages will impact brain gene expressi...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-70732 | biostudies-arrayexpress
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