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Unknown2,2,6-Trimethyl-5-[2-(4-methyl-phen-yl)ethyn-yl]-4H-1,3-dioxin-4-one.
The 1,3-dioxin-4-one ring in the title compound, C(16)H(16)O(3), is in a half-boat conformation with the quaternary O-C(CH(3))(2)-O atom lying 0.546 (1) Å out of the plane defined by the remaining five atoms. The crystal structure is consolidated by C-H⋯O contacts that lead to supra-molecular layers...
S-EPMC2971386 | biostudies-literature
ProteomicsPurification of Cross-linked RNA-Protein Complexes by Phenol-Toluol Extraction
Recent methodological advances allowed the identification of an increasing number of RNAbinding proteins (RBPs) and their RNA-binding sites. RNA interactome capture is, however, limited to proteins interacting with polyadenylated RNAs while RBPs associating with nonadenylate RNA classes cannot be pu...
ORGANISM(S): Homo sapiens (Human) Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2019-03-12 | PXD009571 | Pride
Human Lc-msms Shotgun Salmonella Rna-binding proteins Ptex 
ProteomicsProtein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit
Proteostasis must be finely tuned in the nervous system, as it represents an essential feature of neurodevelopment, and dominant pathology in neurodegenerative disease. At the gateway of proteostasis is the ribosome; however, the architecture of ribosomal complexes in the developing mammalian brain ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD014740 | Pride
Development Neocortex Ribosome Ebp1 Proteostasis Orbitrap 
ProteomicsProtein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit
Proteostasis must be finely tuned in the nervous system, as it represents an essential feature of neurodevelopment, and dominant pathology in neurodegenerative disease. At the gateway of proteostasis is the ribosome; however, the architecture of ribosomal complexes in the developing mammalian brain ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD014841 | Pride
Development Neocortex Ribosome Ebp1 Proteostasis 
ProteomicsExpanding the phenotype of NUP85 mutations beyond nephrotic syndrome to Primary autosomal recessive microcephaly and Seckel syndrome spectrum disoders
Primary autosomal recessive microcepahly and Seckel syndrome spectrum disodrers (MCPH-SCKS) include a heterogenous group of autosomal recessive inherited diseases characterized by primary (congenital) microcephaly, the absence of visceral abnormalities and a variable degree of cognitive impairment, ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD018838 | Pride
Human Lc-msms Nup85 Primary fibroblasts 
UnknownHydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE - Coalition V): A double-blind, multicentre, randomised, controlled trial.

Background

Previous Randomised controlled trials (RCT) evaluating chloroquine and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant difference in hospitalisation rates. However, low statistical power precluded definitive answers.

Methods

We conducted a...
S-EPMC8968238 | biostudies-literature
UnknownSoil erosion modelling: A global review and statistical analysis.
To gain a better understanding of the global application of soil erosion prediction models, we comprehensively reviewed relevant peer-reviewed research literature on soil-erosion modelling published between 1994 and 2017. We aimed to identify (i) the processes and models most frequently addressed in...
S-EPMC8140410 | biostudies-literature
UnknownPartial asynchrony of coniferous forest carbon sources and sinks at the intra-annual time scale.
As major terrestrial carbon sinks, forests play an important role in mitigating climate change. The relationship between the seasonal uptake of carbon and its allocation to woody biomass remains poorly understood, leaving a significant gap in our capacity to predict carbon sequestration by forests. ...
S-EPMC11300610 | biostudies-literature
UnknownTreatment of Multisystem Inflammatory Syndrome in Children.

Background

Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.

Methods

We performed an international observational cohort study of clinical and outcome d...
S-EPMC8220965 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.

Background

Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody with highest affinity for aggrega...
S-EPMC10794000 | biostudies-literature
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