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TranscriptomicsPotentiation of regulatory T cell stability and function via a neuropilin-1:semaphorin-4a axis
Regulatory T cells (Treg) represent a critical immunoregulatory component of the immune system. The signals that maintain Treg stability and potentiate their function remain obscure. Here we show that the immune cell surface ligand semaphorin-4a (Sema4a) Sema treated and NRP1 knock outs were compared...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-41185 | biostudies-arrayexpress
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UnknownStructural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses.
Not available
S-EPMC3111262 | biostudies-literature
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UnknownAnalysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.
Not available
S-EPMC2629300 | biostudies-literature
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TranscriptomicsLoss of Foxp3-driven epigenetic modification leads to regulatory T cell insufficiency
Regulatory T cells (Tregs) are responsible for limiting autoimmunity and chronic inflammation. Foxp3 is a transcription factor that acts as a master r...
...eg development reduced. Foxp3gfpis unable to interact with the histone acetyltransferase Tip60, the histone deacetylase HDAC7, and the Ikaros family zinc finger 4, Eos, which leads to reduced Foxp3 acetylation and enhanced K48-linked polyubiquitylation. Collectively this leads to an altered transcriptional landscape and reduced Foxp3-mediated gene repression, notably at the hallmark IL-2 promoter. Loss of controlled Foxp3-driven epigenetic modification leads to Treg insufficiency that causes autoimmunity in prone environments. 16 samples overall split between 2 genotypes (...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-35164 | biostudies-arrayexpress
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TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. W...
...L-35-dependent, Balb/c Tregs, which express high levels of CTSE and enhanced TRAIL expression, are TRAIL-dependent.These data reveal that cross-regulatory pathways exist, which control the utilization of suppressive mechanisms,thereby providing Tregfunctional plasticity. Isolate natural Tregs from the different knockout mouse
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
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UnknownStability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.
Not available
S-EPMC3867145 | biostudies-literature
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UnknownIL-35-mediated induction of a potent regulatory T cell population.
Not available
S-EPMC3008395 | biostudies-literature
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UnknownNeuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation.
Not available
S-EPMC11722393 | biostudies-literature
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UnknownGermline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.
Not available
S-EPMC3314349 | biostudies-literature
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UnknownRegulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.
Not available
S-EPMC3955731 | biostudies-literature
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