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GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
GenomicsComprehensive Epigenomic Analysis Reveals Dynamic Regulatory Programs Of Blood Development
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-02-25 | E-GEOD-69101 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
GenomicsWhole exome sequencing analyses of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib.
Mutations in isocitrate dehydrogenase 2 (IDH2) occur in many cancers including Acute Myeloid Leukemia (AML). In preclinical models mutant IDH2 causes partial hemopoietic differentiation arrest. Recently, we showed that single agent Enasidenib, a first-in-class, selective mutant IDH2 inhibitor, produ...
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6299 | biostudies-arrayexpress
UnknownA histidine aspartate ionic lock gates the iron passage in miniferritins from Mycobacterium smegmatis.
Not available
S-EPMC4036245 | biostudies-literature
ProteomicsSelection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), there is a relative paucity of studies at the protein level. Here, we perform a deep, multi-omic characterization (epigenome, transcriptome and proteome) of HSCs carrying a loss-of-funct...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-13 | PXD059814 | Pride
Hematopoietic stem cell Extracellular matrix molecules 
UnknownDownregulation of the Central Noradrenergic System by <i>Toxoplasma gondii</i> Infection.
Not available
S-EPMC6346129 | biostudies-literature
UnknownLow-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion.
Not available
S-EPMC12847853 | biostudies-literature
UnknownRNAmut: robust identification of somatic mutations in acute myeloid leukemia using RNA-sequencing.
Not available
S-EPMC7271607 | biostudies-literature
UnknownGenome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Not available
S-EPMC9355874 | biostudies-literature
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