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TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12379 | biostudies-arrayexpress
ProteomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [metabolomics]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12381 | biostudies-arrayexpress
TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [Luminex]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12380 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Seq]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46688 | biostudies-arrayexpress
UnknownGrowth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA.
Not available
S-EPMC7262792 | biostudies-literature
TranscriptomicsGlobal discovery and characterization of small non-coding RNAs in marine microalgae
Background: Marine phytoplankton are responsible for 50% of the CO2 that is fixed annually worldwide and contribute massively to other biogeochemical cycles in the oceans. Diatoms and coccolithophores play a significant role as the base of the marine food web and they sequester carbon due to their a...
ORGANISM(S): Thalassiosira pseudonana CCMP1335 
2015-03-06 | E-GEOD-57987 | biostudies-arrayexpress
UnknownEmergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.
Not available
S-EPMC5214982 | biostudies-literature
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Affymetrix]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46686 | biostudies-arrayexpress
TranscriptomicsSmoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2
Rationale: Genome-wide association studies (GWAS) and candidate gene studies have identified a number of loci linked to susceptibility of chronic obstructive pulmonary disease (COPD), a smoking-related disorder that originates in the airway epithelium. Objectives: Since airway basal cell (BC) stem/p...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-47718 | biostudies-arrayexpress
TranscriptomicsStandardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses
The study employs a standardized whole-blood stimulation systems to test the hypothesis that responses to Toll-like receptor ligands or whole microbes can be defined by the combined transcriptional signatures of key effector cytokines. The study encompasses the analysis of 21 distinct whole blood st...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-85176 | biostudies-arrayexpress
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