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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
UnknownSomatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.
Not available
S-EPMC4207878 | biostudies-literature
UnknownDoxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]).
Not available
S-EPMC4026580 | biostudies-literature
ProteomicsMulti-omics Characterization of Neutrophil Extracellular Trap Formation in Severe and Mild COVID-19 Infections
Analysis of human plasma from patients either infected or not infected with COVID-19
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-28 | MSV000089330 | MassIVE
UnknownBortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation.
Not available
S-EPMC3434979 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of human cell lines with oestrogen receptor (ER), the E2F transcription factor 4 (E2F4),
The Goal of the experiment was to validate the predicted regulatory modules identified by an algorithm.For this we took advantage of the the genome-wide location analysis technique (or ?ChIP/chip?). We selected modules predicted to be bound by the estrogen receptor (ER), the E2F transcription factor...
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-471 | biostudies-arrayexpress
ModelsHeitzler2012 - GPCR signalling
This model is from the article: Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crépieux P, Poupon A, Clément F, Fages F, Lefkowit...
2024-09-02 | BIOMD0000000842 | BioModels
TranscriptomicsRNA-Seq of human skeletal muscle cell line AB1167, with groups of PRDX2 KD, treated with electrical stimulation and both 2.5 and 5uM H202 for 15 minutes
This study investigates the role of peroxiredoxin 2 (PRDX2) in mediating oxidative adaptations in human skeletal muscle myotubes subjected to mechanical contraction and hydrogen peroxide (H2O2) exposure. additionally, the effect of an electrical stimulation protocol was assessed pre and post PRDX2 K...
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14577 | biostudies-arrayexpress
ProteomicsStructure of an Archaeal Ribosome Reveals a Divergent Active Site and Hibernation Factor
Ribosomes translate mRNA into protein. Despite divergence in ribosome structure over the course of evolution, the catalytic site, known as the peptidyl transferase center (PTC), is thought to be nearly universally conserved. Here, we identify clades of archaea that have highly divergent ribosomal RN...
ORGANISM(S): Pyrobaculum calidifontis 
2025-06-17 | PXD064958 | Pride
Lc-ms/ms Ribosome Pyrobaculum calidifontis 
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