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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
TranscriptomicsRespective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma
Phenotypic and genomic characterization of Early Stage Breast Carcinoma using Training set (n=109) Validation set (n=105) of SNP6 arrays Affymetrix SNP6.0 arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved breast tumoral samples.
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-48064 | biostudies-arrayexpress
TranscriptomicsSpecific IMPC gene expression signature
Polarity defects are a hallmark of most carcinomas. Cells from invasive micropapillary carcinomas (IMPCs) of the breast are characterized by a striking cell polarity inversion and represent a good model for the analysis of polarity abnormalities. We have performed an in-depth investigation of polari...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-66418 | biostudies-arrayexpress
TranscriptomicsSNP6 profiling of metaplastic breast carcinoma
SNP6 profiling of metaplastic breast carcinoma Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic type of breast cancer, preferentially displaying a triple-negative phenotype (i.e. lacking estrogen receptor, progesterone receptor and HER2 expression). We sought to define the tran...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57548 | biostudies-arrayexpress
TranscriptomicsIGR_BREAST_EXON_AGILENT_STUDY_FA
We profiled breast cancer samples with exon arrays (244K Agilent Human exon) in order to identify exons associated with higher risk of relapse. This set contain 178 single dual color of samples (biopsies) versus normal breast reference (Normal breast Clontech) , 5 dye-swap (10 hybridizations) and...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-MTAB-1389 | biostudies-arrayexpress
TranscriptomicsExpression profiling of invasive breast carcinoma samples from Institut Curie
Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas to appear in Internationa Journal of Cancer Transcriptome analysis of 243 (plus 12 duplicates) primary breast invasive carcinoma samples of various molecular subtypes. This dataset contains 255 arrays for 243 prim...
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-69986 | biostudies-arrayexpress
UnknownA catalog of numerical centrosome defects in epithelial ovarian cancers
Not available
S-SCDT-EMM-2022-15670 | biostudies-other
UnknownAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-62966 | biostudies-other
TranscriptomicsGenomic profiling of ductal breast carcinoma to identify high risk small node negative breast cancer patients
Abstract: Purpose: To identify a DNA signature to predict metastasis of small node-negative breast carcinoma Experimental Design: The authors used Comparative Genomic Hybridization (CGH) array to analyze 168 pT1T2pN0 invasive ductal carcinoma patients with either good (no event 5 years after diag...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-19159 | biostudies-arrayexpress
TranscriptomicsHuntington disease protein accelerates tumour development and metastasis
Huntington disease is a severe neurological disorder caused by an abnormal polyglutamine expansion in the N-terminal of the huntingtin protein. Here we show that breast tumours appear earlier when mutant huntingtin is expressed in an activated polyomavirus middle T antigen (PyVT) mouse breast cancer...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-28685 | biostudies-arrayexpress
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