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Despite the continuous emergence of multi-drug resistant pathogens, the number of new antimicrobials reaching the market is critically low. Natural product peptides are a rich source of bioactive compounds, and advances in mass spectrometry have achieved unprecedented capabilities for the discovery ...
ORGANISM(S): Viola inconspicua 
2020-09-04 | PXD020857 | Pride
Stable and commonly bioactive cysteine-rich peptides (CRPs) have are typically discovered via mass shift analysis. However, the accurate assessment of unique CRP species in a given botanical species is often challenged by same mass species, post-translational modifications or modifications derived f...
ORGANISM(S): Lagenaria siceraria Viola <eudicots> 
2020-09-04 | PXD019501 | Pride
The recent increase in extensively drug resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide d...
ORGANISM(S): Viola odorata 
2017-01-02 | PXD004780 | Pride
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