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GenomicsCombinitorial Approaches to Viral Attenuation
Combinitorial Approaches to Viral Attenuation
PRJNA474818 | ENA
TranscriptomicsAffect of antiviral ribavirin on YFV WT and vaccine strains.
Live-attenuated viral vaccines have been successfully used to combat infectious disease for decades but due to their empirical derivation, little is known about their mechanisms of attenuation. This lack of understanding makes the development of next generation live attenuated vaccines difficult. Th...
ORGANISM(S): Yellow fever virus 
2020-01-01 | E-MTAB-8504 | biostudies-arrayexpress
TranscriptomicsDifferentially-expressed miRNAs in MDBK cells infected with bovine viral diarrhea virus compared to MDBK cells
Non-canonical microRNAs (miRNAs) are a class of short endogenous RNA molecules with the ability to control development, autophagy, apoptosis and the stress response in eukaryotes by pairing with partially complementary sites in the 3' untranslated regions (UTRs) of targeted genes. Recent studies hav...
ORGANISM(S): Bos taurus 
2014-12-16 | E-GEOD-61251 | biostudies-arrayexpress
TranscriptomicsCombinitorial Approaches to Viral Attenuation
Attenuated viruses have numerous applications, in particular in the context of live viral vaccines. However, purposefully designing attenuated viruses remains challenging, in particular if the attenuation is meant to be resistant to rapid evolutionary recovery. Here we develop and analyze a new atte...
ORGANISM(S): Escherichia phage T7 
2018-06-07 | GSE115396 | GEO
TranscriptomicsDegradation of cellular miR-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report tha...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-34475 | biostudies-arrayexpress
UnknownCombinatorial Approaches to Viral Attenuation.
Not available
S-EPMC6068830 | biostudies-literature
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
UnknownViral attenuation by engineered protein fragmentation.
Not available
S-EPMC6009699 | biostudies-literature
ProteomicsReduced protein expression in a virus attenuated by codon deoptimization
A general means of viral attenuation involves the extensive recoding of synonymous codons in the viral genome. The mechanistic underpinnings of this approach remain unclear, however. Using quantitative proteomics and RNA sequencing, we explore the molecular basis of attenuation in a strain of bacte...
ORGANISM(S): Enterobacteria phage T7 Escherichia coli (strain K12) 
2018-10-24 | PXD006502 | Pride
Codon deoptimization Codon usage Viral attenuation 
UnknownEvolutionary dynamics of viral attenuation.
Not available
S-EPMC136581 | biostudies-literature
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