Sort   by:  
 Page size 
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
MetabolomicsPseudorabies Virus Triggers Ferritinophagy-Mediated Ferroptosis and Neuroinflammation in Viral Encephalitis

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified...

2026-04-17 | MTBLS12373 | MetaboLights
MetabolomicsBrain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoids (CBOs) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found t...
2026-06-18 | MTBLS14790 | MetaboLights
ModelsAlmuallem2020 - Virus-macrophage-tumour interactions in oncolytic viral therapies
This mathematical model of the role of the innate immune responses generated by macrophages in the context of anti-tumour oncolytic viral therapies is described in the publication: Nada Almuallem, Dumitru Trucu, Raluca Eftimie. "Oncolytic viral therapies and the delicate balance between virus-macrop...
2024-09-02 | BIOMD0000001033 | BioModels
Immuno-oncology 
GenomicsLarge-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients
Despite the high global prevalence of chronic hepatitis B (CHB) infection, datasets covering the whole hepatitis B viral genome from large patient cohorts are lacking, greatly limiting our understanding of the viral genetic factors involved in this deadly disease. We performed deep sequencing of vir...
EGAS00001003689 | EGA
TranscriptomicsNon-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach
The analysis compares primary fibroblasts initially used for reprogramming, established marmoset ES cells and a marmoset iPS cell line which was generated witha non-viral approach using a six-factor-in-one-vector approach Cells were grown under standard conditions for marmoset pluripotent stem cell...
ORGANISM(S): Callithrix jacchus 
2015-04-08 | E-GEOD-64966 | biostudies-arrayexpress
UnknownToll-like receptor-agonist-based therapies for respiratory viral diseases: thinking outside the cell.
Not available
S-EPMC9488969 | biostudies-literature
GenomicsHigh-Throughput 5’ UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies
High-Throughput 5’ UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies
PRJNA736738 | ENA
UnknownAntiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry.
Not available
S-EPMC4431382 | biostudies-literature
ProteomicsTop-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction
Here, we present our investigation of the viral proteins of the capsid of adeno-associated viruses via top-down mass spectrometry on the LC timescale. Characterization was improved through the use of proton transfer charge reduction
ORGANISM(S): Human Aav 
2024-06-14 | MSV000095045 | MassIVE
Sort   by:  
 Page size