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ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD000685 | Pride
Human vlp protein complex 
ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080790 | MassIVE
ProteomicsPhosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) facilitates recruitment of multiple SH2/SH3 proteins including Grb2.
B-cell adaptor protein (BCAP) is a multimodular, multi-functional signal transducer that regulates signal transduction processes in leukocytes including macrophages, B-cells and T-cells. In particular BCAP acts as a negative regulator of inflammatory signaling by the Toll-like receptors. Here we cha...
ORGANISM(S): Homo sapiens (Human) 
2019-09-16 | PXD014410 | Pride
Sh2 domains Toll-like receptors Phosphoinositide 3-kinase Human cell line hek293t bcap Phosphorylation Sh3 domains 
UnknownTrapping mammalian protein complexes in viral particles.
Not available
S-EPMC4853472 | biostudies-literature
ProteomicsLoss-of-function of ubiquitin ligase adaptor LZTR1 triggers human disease by dysregulating RAS ubiquitination
Mutations in LZTR1, a substrate adaptor for cullin 3 (CUL3) ubiquitin ligase complexes1, have been recently associated with Noonan syndrome2,3 and familial Schwannomatosis4-6. Concordantly, we found that Lztr1+/- mice showed craniofacial abnormalities, cardio defects, and premature ageing; whereas l...
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD007049 | Pride
Virotrap protein complex 
ProteomicsOrthogonal interactome profiling of RNF41
Ring finger protein 41 (RNF41) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of many proteins such as ErbB3 receptors, BRUCE and parkin. Next to this, RNF41 regulates the intracellular trafficking of certain JAK-2 associated cytokine receptors by ubiquitinating and suppres...
ORGANISM(S): Homo sapiens (Human) 
2018-03-26 | PXD007794 | Pride
Human ap-ms viortrap bioid 
UnknownPhosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
Not available
S-EPMC6937578 | biostudies-literature
ProteomicsCheck of selected NTR peptide spectra by comparison with synthetic peptides
Ribosome profiling has revealed translation outside of canonical coding sequences (CDSs) including translation of short upstream ORFs, long non-coding RNAs, overlapping ORFs, ORFs in UTRs or ORFs in alternative reading frames. Studies combining mass spectrometry, ribosome profiling and CRISPR-based ...
ORGANISM(S): Homo Sapiens 
PXD030285 | panorama
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